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Health: What Is the Cause of These Allergies? It is possible that this is an evolutionary strategy.

We are aware of their functionality; however, the rationale behind their development remains obscure. Carl Zimmer describes his encounter with immunologist Ruslan Medzhitov, who has a novel allergy theory.

Hornets were the culprit for me.

It was a balmy afternoon. I was 12 years old and was sprinting through a wild field in close proximity to a friend’s residence. I kicked a hornet’s colony the size of a football. My leg was invaded by a swarm of enraged insects. Their wounds were unpleasant, resembling hot needles. I struck them away and fled for assistance; however, I soon realized that there was an additional issue. Pink dots had formed a constellation around the wounds. The rash on my epidermis was ascending my legs and causing swelling.

I was experiencing an allergic reaction.

Antihistamines were administered to me by my mother’s acquaintance, who then transported me to her vehicle. I became increasingly frightened as we traveled to the county hospital. I had a hazy understanding of the catastrophic consequences that can result when allergies manifest. I envisioned hives that were engulfing my larynx and causing me to choke.

However, I survived to recount this narrative.

After receiving treatment at the hospital, the rash resolved, but I was left with an intense apprehension toward hornets. Subsequently, an allergy test verified that I am allergic to hornets—not bees or wasps, but the specific species that struck me.

The physician in the emergency room informed me that I may not be as fortunate if it were to occur again. She provided me with an EpiPen and instructed me to administer it to my limb in the event that it occurs again. Epinephrine is likely to save my life, as it elevates blood pressure and opens the airways. I was fortunate; it transpired on a particular afternoon 35 years ago, and I have not encountered another hornet’s nest since.

Years ago, I misplaced my EpiPen.

The collective burden of allergies is substantial, but there are only a few treatments available. The EpiPen has the potential to save lives; however, the long-term treatments that are currently available are dubious for individuals who are exhausted by mold allergies or the annual release of pollen. Antihistamines frequently alleviate symptoms; however, sluggishness and lethargy are common side effects, as with other treatments.

What is transpiring within the body?

If scientists were to comprehend allergies, they could develop more effective treatments. Nevertheless, allergic reactions are the result of a complex interplay of factors, including the release of chemicals, the malfunction of cells, and the regulation of signaling. Scientists have only mapped out a portion of the process. And this biochemical web is underpinned by an even more profound mystery:

What is the reason for the existence of allergies?

Ruslan Medzhitov recently informed me, “That is the inquiry that intrigues me.” “It is a significant, fundamental issue, but it is entirely unknown.”

As we stroll through his lab on the top floor of the Anlyan Center for Medical Research and Education at Yale School of Medicine, his staff of postdocs and residents work among large tanks of oxygen and incubators filled with immune cells. “It is a significant mess, but it is productive,” he informs me with a shrug. Medzhitov’s face resembles a boxer’s, massive, round, with a broad, flat nose, but he speaks with a soft elegance.

Medzhitov’s “mess” has been exceedingly advantageous.

A NEW THEORY. Now Medzhitov is tackling a question that could change immunology again: Why do we get allergies? No definitive answer exists, but the most widely accepted theory suggests that allergies are a botched defence mechanism against intestinal parasites. In the industrialised world, where infections are rare, this system overreacts against harmless targets, making us feel sick.

Medzhitov contends that this theory is inaccurate.

Allergies aren’t just a biological mistake. Instead, they’re an essential defence against harmful chemicals, one that served our ancestors for tens of millions of years and continues to this day. Medzhitov admits it’s a controversial theory, but he’s confident history will prove him right. “I think there’s going to be much resistance to the idea for a while,” he tells me. “And then everyone will start saying, ‘Oh yeah, that’s clear, that’s obvious.’ ”

Sunday, was 65 years old

For me, it all started around the age of 40 with a series of allergies, rhinitis and a runny nose, 12 months a year without a break. At first, I thought they were just colds. I took antihistamines, but they didn’t work.

Then, after the allergy test, they gave me sprays to do twice a day, but over the years, the situation kept getting worse. I also started having breathing problems, constant cough, and tightness in my chest.

I struggled to do everything, even cleaning the house.

After almost 20 years of this agony, I was giving up. I was told that I would have to live with it, but then two years ago, after a series of more in-depth tests, I was finally diagnosed with Severe Asthma.

Thanks to the support of my pulmonologist, I was included in the biological therapy program. I do one treatment a month, and my life has changed; I feel reborn. Of course, I still spray twice a day and take an antihistamine pill in the evening, but I no longer feel that constant suffocation sensation that I had before.

I get tired, but I can handle the situation.

I no longer have rhinitis, colds and bronchitis. I no longer have a cough that used to be constant all year, all day. Above all, I have started volunteering again, a passion that I have always had that makes me feel mentally and physically good.

As a volunteer, I work in emergencies, and it was bad not to be able to run, climb stairs, or not to support those who needed it. Now, however, I feel useful again because I can help others. I have also returned to being able to do cardiac massages. And all this is thanks to the right diagnosis.

ALLERGY TO INHALANTS

Debby had been suffering from allergic reactions for years when he accidentally bit his lip and came into contact with inhalants. To avoid swelling that started from the lip, red skin patches associated with burning and other unpleasant symptoms, he was forced to take antihistamines and cortisone, and the situation was rapidly worsening.

There was no logical connection for certain reactions occurring at any time of the year. During the allergic reaction, as he reports in the following testimony, his lower lip reached his nose because of how swollen it was. He diligently went through the entire Total Reset process, also carefully addressing emotional blocks.

What is Next

Today, he has stopped taking any medicine, and since the end of the treatments, there have been no more symptoms of any type or intensity.

“It’s been a long time since I started suffering from allergies, but in recent years, the episodes have intensified to the point of requiring the use of antihistamines and cortisone drugs, and on one occasion, I had to seek emergency care.

They told me about the Total Reset method in January of this year. Encouraged by my life partner, I participated in an initial interview with Debby, who explained how the entire process would unfold and what techniques and procedures to implement.

Its the End?

The entire cycle of weekly sessions ended at the end of July. During the process, there were restrictions to be followed with care and attention, particularly on what foods to eat in the hours following each treatment and what to avoid.

There were positive signs right from the start, followed by moments in which some allergic reactions occurred, albeit milder. But this did not discourage me from continuing the treatment, also because I was aware that this could happen.

Despite some small sacrifices, I can finally say that I feel good today because I consistently applied the method.

For this, I want to thank Debby for her dedication, determination, and professionalism. She accompanied me through every phase of the treatment.

Thank you